[HTML][HTML] Functional expression of two KvLQT1-related potassium channels responsible for an inherited idiopathic epilepsy
WP Yang, PC Levesque, WA Little, ML Conder… - Journal of Biological …, 1998 - ASBMB
Benign familial neonatal convulsions (BFNC), a class of idiopathic generalized epilepsy, is
an autosomal dominantly inherited disorder of newborns. BFNC has been linked to
mutations in two putative K+ channel genes, KCNQ2 andKCNQ3. Amino acid sequence
comparison reveals that both genes share strong homology to KvLQT1, the potassium
channel encoded byKCNQ1, which is responsible for over 50% of inherited long QT
syndrome. Here we describe the cloning, functional expression, and characterization of K+ …
an autosomal dominantly inherited disorder of newborns. BFNC has been linked to
mutations in two putative K+ channel genes, KCNQ2 andKCNQ3. Amino acid sequence
comparison reveals that both genes share strong homology to KvLQT1, the potassium
channel encoded byKCNQ1, which is responsible for over 50% of inherited long QT
syndrome. Here we describe the cloning, functional expression, and characterization of K+ …
