Accelerated telomere reduction and hepatocyte senescence in tolerated human liver allografts
W Aini, A Miyagawa-Hayashino, M Ozeki, S Adeeb… - Transplant …, 2014 - Elsevier
Background In living donor liver transplantation, the biological organ age of the donated
allograft is unknown in young patients who receive grafts from older donors. Few studies
have focused on the effects of aging on allografts in the state of tolerance. The purpose of
this study was to assess the biological organ age of liver grafts. Methods In 20 tolerated
allografts over a 10-year post-transplant follow-up period, the relative telomere lengths were
measured by multiplex quantitative polymerase chain reaction, and hepatocyte nuclear size …
allograft is unknown in young patients who receive grafts from older donors. Few studies
have focused on the effects of aging on allografts in the state of tolerance. The purpose of
this study was to assess the biological organ age of liver grafts. Methods In 20 tolerated
allografts over a 10-year post-transplant follow-up period, the relative telomere lengths were
measured by multiplex quantitative polymerase chain reaction, and hepatocyte nuclear size …
