Omicron severe acute respiratory syndrome coronavirus 2 neutralization by immunoglobulin preparations manufactured from plasma collected in the United States …
MR Farcet, M Karbiener, S Knotzer… - The Journal of …, 2022 - academic.oup.com
MR Farcet, M Karbiener, S Knotzer, J Schwaiger, TR Kreil
The Journal of infectious diseases, 2022•academic.oup.comAfter> 2 years of the coronavirus disease 2019 (COVID-19) pandemic, immunoglobulins
(IGs) contain highly potent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
neutralizing antibodies, based on the large proportion of United States (US) plasma donors
who have gone through COVID-19 or vaccination against the virus. Neutralization of
Omicron SARS-CoV-2 by antibodies generated after non-Omicron infection or vaccination
has been lower though, raising concerns about the potency of IG against this new virus …
(IGs) contain highly potent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
neutralizing antibodies, based on the large proportion of United States (US) plasma donors
who have gone through COVID-19 or vaccination against the virus. Neutralization of
Omicron SARS-CoV-2 by antibodies generated after non-Omicron infection or vaccination
has been lower though, raising concerns about the potency of IG against this new virus …
Abstract
After >2 years of the coronavirus disease 2019 (COVID-19) pandemic, immunoglobulins (IGs) contain highly potent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibodies, based on the large proportion of United States (US) plasma donors who have gone through COVID-19 or vaccination against the virus. Neutralization of Omicron SARS-CoV-2 by antibodies generated after non-Omicron infection or vaccination has been lower though, raising concerns about the potency of IG against this new virus variant. Also, as plasma collected in the US remains the main source of IG, the neutralization of SARS-CoV-2 for plasma collected elsewhere has been less well studied. Here, we confirm Omicron neutralization by US as well as European Union plasma–derived IG lots.
Oxford University Press